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tp53 and Li-Fraumeni syndrome - radiation sensitivity

Own studies on radiation sensitivity:

On average, patients with Li Fraumeni syndrome have significantly increased radiation sensitivity. Only three out of 11 patients have average radiation sensitivity, seven patients have increased radiation sensitivity and one patient has extremely increased radiation sensitivity.

Literature on radiosensitivity measurements:

Literature on clinical case reports/consequences of radiation:

Conclusion regarding testing for radiation sensitivity:

Li Fraumeni patients are on average more sensitive to radiation, but only to a limited extent. Extremely increased radiation sensitivities are possible, where the dose should definitely be adjusted. In addition, Li Fraumeni syndrome patients have a very high risk of developing tumors and secondary tumors after treatment. It is stated that 30% of patients develop a secondary carcinoma within a mean time of 10.7 years. It is therefore generally recommended that radiotherapy should be avoided if possible.

To learn more about radiation sensitivity in Li Fraumeni, we are very interested in testing patients with Li Fraumeni. We are also happy to test people who do not have a tumor. Please get in touch with us.