Radiosensitivity syndromes with high stochastic risk

Individual Radiation Sensitivity Homepage Our studies of radiation sensitivity are primarily concerned with deterministic risk, i.e. avoiding the occurrence of adverse effects of therapy. Stochastic risk is always considered and is likely to be increased in a similar way to deterministic risk. However, there are genetic diseases caused by mutations in tumour suppressor genes where the stochastic risk is much higher than the deterministic risk. These are:

• Li Fraumeni syndrome (p53-Gen)
• Neurofibromatosis Typ I (NF1-Gen, Morbus Recklinghausen)
• Retinoblatoma (RB1-Gen)
• Gorlin-Goltz syndrome (PTCH1/Hedgehog signalling pathway)